Hypolipidemic effects of microencapsulated powder fraction from Hibiscus sabdariffa. L calyx in hyperlipidic rats

The lipid-lowering activity of microencapsulated and nonmicroencapsulated Hibiscus sabdariffa L. powder fractions in rats rendered hyperlipidemic by a hyperlipid diet (HLD) was determined. Dried calyces H. were finely ground fractionated on sieve column to retain particle sizes ϕ < 315 µm, with maltodextrin (MD). Rats randomly divided into four groups: normal control group, group (negative groups), supplemented atorvastatin, non-microencapsulated (NMEPHS) (MEPHS) powders from groups. received NMEPHS MEPHS for three weeks. Atorvastatin (10 mg/kg) individual dissolved water administered at dose 250 mg/kg body weight Body weight, total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL-C), high-density (HDL-C), aspartate transferase (AST), alanine (ALT), superoxide dismutase (SOD), catalase (CAT) malondialdehyde (MDA) measured. Very (VLDL-C), hepatosomatic index (HSI), adiposomatic (ASI) calculated. Lipid profil, MDA increased the negative rat groups compared group. significantly reduced gain, ASI, HSI, TC, TG, LDL-C, ALT, AST, HDL-C level significantly. Moreover, SOD CAT activities HLD HSCP intake. however, most significant revealed MEPHS. These results suggest that exerts potent effects, promotes hepatic fat breakdown, regulates antioxidant enzymes more efficient manner.